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EFFECT OF FURAZOLIDONE AND NITROFURAZONE ON BRAIN GAMMA‐AMINO BUTYRIC ACID AND GLUTAMATE CONCENTRATIONS IN CHICKENS
Author(s) -
Ali B. H.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01572.x
Subject(s) - furazolidone , nitrofurazone , glutamate receptor , butyric acid , chemistry , pharmacology , glutamic acid , amino acid , gamma aminobutyric acid , biochemistry , biology , medicine , receptor , antibiotics , traditional medicine
SUMMARY 1. The concentrations of gamma‐amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose‐dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.