Premium
DILATATION OF THE RIGHT ATRIUM STIMULATES PHOSPHATIDYLINOSITOL TURNOVER
Author(s) -
Harsdorf Rüdiger,
Lang Rudolph E.,
Woodcock Elizabeth A.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01569.x
Subject(s) - phosphatidylinositol , inositol , medicine , endocrinology , inositol phosphate , stimulation , chemistry , right atrium , atrium (architecture) , signal transduction , biochemistry , receptor , atrial fibrillation
SUMMARY 1. Dilatation of the rat right atria caused a stimulation of the phosphatidylinositol turnover pathway as measured by an increase in the accumulation of inositol phosphates in isolated, perfused hearts. 2. In right atria, increases were detected after 1 min dilatation and maximal increases were observed after 10 min. Dilatation for 10 min caused an increase in inositol monophosphate inositol bisphosphate and inositol trisphosphate from 23.3 ± 0.9, 15.4 ± 0.4, and 9.5 ± 0.3 (mean and s.e.m., n = 7 ct/min per mg tissue) to 74.6 ± 2.3, 20.2 ± 1.3 and 13.6 ± 1.5 ( n = 8), respectively ( P < 0.01 for all inositol phosphates.) 3. These results show that the myocardium can respond to dilatation by an activation of the phosphatidylinositol turnover pathway.