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PHAEOCHROMOCYTOMAS SECRETING ADRENALINE BUT NOT NORADRENALINE DO NOT CAUSE HYPERTENSION AND REQUIRE PRECISE ADRENALINE MEASUREMENT FOR DIAGNOSIS
Author(s) -
Bachmann Anthony W.,
Hawkins Peter G.,
Gordon Richard D.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01557.x
Subject(s) - medicine , urinary system , pheochromocytoma , excretion , clonidine , endocrinology , diagnostic test , epinephrine , endocrine system , urology , hormone , pediatrics
SUMMARY 1. Urinary noradrenaline (NA) and adrenaline (ADR) determinations are a more sensitive index than plasma measurements for the diagnosis of phaeochromocytoma (phaeo). 2. Even though urinary NA excretion serve as a sufficient single diagnostic test for the majority of phaeos, it is necessary to measure urinary ADR excretion if ADR‐only secreting phaeos are not to be missed, particularly in patients with multiple endocrine neoplasia (MEN) syndrome. 3. The clonidine suppression test confirmed all tumour diagnoses, and in this series was not responsible for any false negative or false positive results.