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LEVELS OF ATRIAL NATRIURETIC PEPTIDE ARE NOT ALWAYS CONSISTENT WITH ATRIAL PRESSURE: IS THERE ALTERNATIVE REGULATION AS EVIDENCED IN GORDON'S AND BARTTER'S SYNDROMES?
Author(s) -
Klemm Shelley A.,
Gordon Richard D.,
Tunny Terry J.,
Hawkins Peter G.,
Finn Wendy L.,
Hamlet Stephen M.,
Kewal Narendra K.,
Purton Karen J.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01556.x
Subject(s) - atrial natriuretic peptide , medicine , cardiology , endocrinology
SUMMARY 1. In Bartter's syndrome, atrial pressures were low, consistent with volume contraction, while atrial natriuretic peptide (ANP) levels were unexpectedly elevated. Infusion of normal saline increased both right atrial pressure (RAP) and ANP levels, while administration of prostaglandin inhibitors raised RAP, probably due to volume expansion, but ANP levels fell paradoxically. 2. In Gordon's syndrome, atrial pressures were unexpectedly low or normal despite volume expansion, while ANP levels were normal. Pressor infusions of angiotensin II either raised right and left atrial pressures (LAP) without increasing ANP, or increased ANP without increasing atrial pressures. 3. In these two syndromes, atrial pressures and ANP levels were poorly correlated, leading to the proposal that other regulators of ANP may be important.