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ENDOTHELIN IS BLOOD VESSEL SELECTIVE: STUDIES ON A VARIETY OF HUMAN AND DOG VESSELS IN VITRO AND ON REGIONAL BLOOD FLOW IN THE CONSCIOUS RABBIT
Author(s) -
Cocks T. M.,
Broughton A.,
Dib M.,
Sudhir K.,
Angus J. A.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01551.x
Subject(s) - vasoconstriction , vasodilation , medicine , blood vessel , endocrinology , contraction (grammar) , angiotensin ii , endothelin 1 , femoral artery , endothelin receptor , blood flow , endothelins , endothelium , vascular resistance , anatomy , chemistry , hemodynamics , blood pressure , receptor
SUMMARY 1. Endothelin (Et), a vasoconstrictor peptide, was 5–10‐fold more potent (lower EC 50 ) on isolated ring segments of large veins than on large arteries removed from dog coronary, mesenteric, femoral, renal and internal mammary vasculature and from the human internal mammary pedicle. 2. In the dog large coronary artery, Et (10–30 nmol/L) caused transient relaxations partway through the generation of a concentration‐contraction curve. These relaxations were endothelium dependent. 3. In conscious rabbits treated with mecamylamine, Et (0.025–0.4 nmol/kg) caused a marked rise in renal vascular resistance but hindquarter vasodilation. Under the same conditions angiotensin II constricted both beds. 4. These studies suggest that Et is vascular bed and large vein selective in activity. It did not appear to be selective for large or small coronary arteries in vitro.