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PARADOXICAL EFFECTS OF ENDOTHELIN ON CARDIOVASCULAR NORADRENERGIC NEUROTRANSMISSION
Author(s) -
WongDusting H. K.,
Reid J. J.,
Rand M. J.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01548.x
Subject(s) - chronotropic , medicine , endocrinology , endothelin receptor , isoprenaline , endothelin 3 , endothelin 1 , inotrope , endothelins , stimulation , vasoconstriction , circulatory system , perfusion , contraction (grammar) , chemistry , blood pressure , receptor , heart rate
SUMMARY 1. Pre‐ and postjunctional effects of endothelin (1–10 nmol/L) have been studied in the rabbit isolated ear artery and in rat isolated atria. 2. Endothelin produced concentration‐dependent increases in arterial perfusion pressure, and had positive chronotropic and inotropic effects in rat atria. 3. Vasoconstrictor responses of the arteries to sympathetic nerve stimulation were reduced by 1 nmol/L endothelin and abolished by 10 nmol/L endothelin. In rat atria, the chronotropic responses to nerve stimulation were markedly reduced by 10 nmol/L endothelin. 4. In rabbit ear artery, vasoconstrictor responses to noradrenaline were enhanced by 1 nmol/L endothelin, but were reduced by 10 nmol/L endothelin. In rat atria, endothelin reduced the chronotropic response to isoprenaline. 5. Endothelin (10 nmol/L) increased the stimulation‐induced release of radioactivity in arteries and atria labelled with [ 3 H]‐noradrenaline by 91% and 23%, respectively. 6. The p‐ and postjunctional effects of endothelin persisted in both arterial and atrial preparations for at least 30 min after its removal.