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NATRIURETIC AND HYPOTENSIVE EFFECTS OF BRAIN NATRIURETIC PEPTIDE IN ANAESTHETIZED DOCA‐SALT HYPERTENSIVE RATS
Author(s) -
Kita Toshihiro,
Kida Osamu,
Kato Johji,
Nakamura Shigeru,
Eto Tanenao,
Minamino Naoto,
Kangawa Kenji,
Matsuo Hisayuki,
Tanaka Kenjiro
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01543.x
Subject(s) - natriuresis , brain natriuretic peptide , medicine , endocrinology , natriuretic peptide , atrial natriuretic peptide , peptide hormone , blood pressure , receptor , heart failure
SUMMARY 1. Both natriuretic and hypotensive effects of brain natriuretic peptide (BNP), a novel peptide identified in porcine brain, were investigated in anaesthetized DOCA‐salt rats and control rats. 2. An intravenous injection of two different doses (0.5 and 5.0 nmol/kg) of BNP produced a rapid and marked natriuresis and hypotension in DOCA‐salt rats. 3. In particular, significant differences of responsiveness were observed between DOCA‐salt and control rats when administered the lower dose of BNP. 4. It was suggested that DOCA‐salt rats might be relatively more susceptible to BNP.