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PLASMA, CARDIAC TISSUE AND BRAIN MORPHINE CONCENTRATIONS IN ACUTE AND CHRONIC MORPHINE‐TREATED RATS
Author(s) -
Ko Wendy WW.,
Dai Soter
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01535.x
Subject(s) - morphine , medicine , plasma concentration , anesthesia , pharmacology
SUMMARY 1. The plasma, cardiac tissues and brain morphine concentrations in rats after acute or chronic morphine treatment were measured by high‐performance liquid chromatography. 2. Morphine concentrations in plasma and cardiac tissues were found to be significantly higher than those in brain after acute morphine injection. However, after chronic oral administration, morphine concentrations in plasma, cardiac tissues and brain were similar. 3. Brain concentrations of morphine following chronic administration were higher than those obtained after acute administration although concentrations in plasma and cardiac tissues were lower.