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ROLE OF GABAERGIC SYSTEM IN PROLACTIN ANALGESIA
Author(s) -
Ramaswamy S.,
Suthakaran C.,
Bapna J. S.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01529.x
Subject(s) - prolactin , morphine , gabaergic , analgesic , pharmacology , bicuculline , opioid , endocrinology , medicine , inhibitory postsynaptic potential , gabaa receptor , hormone , receptor
SUMMARY 1. The role of the GABAergic system in the analgesic action of prolactin was investigated using a pharmacological approach. 2. THIP, a GABAmimetic, per se produced an analgesic effect and potentiated the analgesic effect of prolactin and morphine. 3. Bicuculline, in subconvulsive doses, per se did not alter the number of writhings, while it attenuated the analgesic effect of prolactin. 4. These results indicate a positive role for the GABAergic system in prolactin induced analgesia. 5. Since THIP resembles morphine and because prolactin possesses several other morphine‐like functions, it is possible that the role played by GABA may be an opioid‐related one.