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CALMODULIN‐ANTAGONIST DRUGS AND PORCINE MALIGNANT HYPERPYREXIA
Author(s) -
Collins S. P.,
White M. D.,
Denborough M. A.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01103.x
Subject(s) - antagonist , calmodulin , halothane , caffeine , contracture , endocrinology , pharmacology , medicine , chemistry , muscle relaxant , anesthesia , calcium , receptor , surgery
SUMMARY 1. Landrace swine were identified as malignant hyperpyrexia susceptible (MHS) or control by the contracture responses of gracilis muscle fibre bundles to 3% halothane, 2 mmol/l caffeine and 80 mmol/l KCI. The effects of calmodulin‐antagonist drugs on the contractile behaviour of control and MHS preparations were investigated in vitro. 2. Calmodulin‐antagonists at micromolar concentrations induced contracture in both control and MHS muscle. Pretreatment of MHS muscle with calmodulin‐antagonist drugs potentiated its response to halothane and caffeine. 3. These results suggest that calmodulin‐antagonist drugs cause an increase in myoplasmic Ca 2+ concentration in both control and MHS muscle.