Premium
EFFECT OF GLYCAEMIC CONTROL ON GLOMERULAR FILTRATION RATE IN THE STREPTOZOTOCIN DIABETIC RAT
Author(s) -
Jackson B.,
Franze L.,
Allen T. J.,
O'Brien R.,
Cooper M.,
Hodsman G. P.,
Jerums G.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01088.x
Subject(s) - streptozotocin , medicine , endocrinology , renal function , diabetes mellitus , insulin , plasma glucose
SUMMARY 1. Diabetes was induced in 32 adult Wistar‐Kyoto rats with streptozotocin (60 mg/kg). Fourteen rats remained untreated, 10 received insulin three times per week, and eight received insulin daily. Fourteen non‐diabetic rats served as controls. 2. Exchangeable sodium and plasma volume were elevated in the untreated diabetic rats. Treatment normalized these parameters, 3. Glomerular filtration rate (GFR) was elevated in the untreated diabetic group and the group receiving insulin three times per week compared with the control group. Daily insulin treatment restored GFR towards control values. 4. Plasma atrial natriuretic factor was similar in untreated diabetic rats and non‐diabetic rats.