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HIGH SALT DIET DECREASES LONGEVITY IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Author(s) -
Nicolantonio R.,
Silvapulle M. J.,
Spargo S.,
Morgan T. O.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01087.x
Subject(s) - blood pressure , medicine , longevity , endocrinology , body weight , gerontology
SUMMARY 1. Blood pressure, body weight and mortality rate were examined in female spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on a lifelong high (5% NaCl w/w) or low (0.1% NaCl w/w) salt diet. 2. A high salt diet increased mortality and decreased body weight in SHR, but failed to significantly alter blood pressure up to 24 months of age. 3. Hence, a low salt diet does not appear to be a long‐term risk factor and may protect the SHR from cardiovascular accidents.