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THREE Alu REPEATED SEQUENCES ASSOCIATED WITH A HUMAN GLANDULAR KALLIKREIN GENE
Author(s) -
Schedlich Lynette J.,
Morris Brian J.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01084.x
Subject(s) - kallikrein , gene , genetics , biology , alu element , human genome , genome , biochemistry , enzyme
SUMMARY 1. Recently the complete primary structure of a human glandular kallikrein gene, hGK‐1, was reported. The present paper presents further structural information. 2. Associated with the gene were three Alu repeated sequences: one in the second intron and two approximately 0.4 kb and 1.2 kb upstream. 3. The 5′ non‐coding and 5′ flanking DNA was highly homologous to that in the mouse genes. 4. Different polyadenylation signals are used in different human kallikrein genes.