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SERUM LIPIDS IN INSULIN‐DEPENDENT DIABETICS ARE MARKEDLY ALTERED BY DIETARY FISH OILS
Author(s) -
Mori Trevor A.,
Vandongen Robert,
Masarei John R. L.,
Dunbar Diana,
Stanton Kim G.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01083.x
Subject(s) - fish oil , medicine , endocrinology , eicosapentaenoic acid , cholesterol , arachidonic acid , subclass , chemistry , high density lipoprotein , insulin , fish <actinopterygii> , polyunsaturated fatty acid , fatty acid , biology , biochemistry , enzyme , immunology , antibody , fishery
SUMMARY 1. The effect of dietary fish oil supplementation on serum lipids was examined in normolipidaemic insulin‐dependent male diabetics and healthy controls. Fish oil was given as Max eicosapentaenoic acid (EPA), 15 g daily (equivalent to 2.7 g/day of EPA) for 3 weeks. 2. There was a substantial increase in EPA but a depletion of arachidonic acid content of platelet phospholipids. 3. Diabetics showed a rise in total cholesterol, attributable to increases in low density and high density lipoprotein (LDL and HDL) cholesterol. The rise in HDL cholesterol was largely due to an increase in its HDL 2 subclass. Similar changes were found in the healthy men although these were not as marked. A decrease in triglycerides was observed in both diabetics and normal controls. 4. Generally, diabetics showed greater changes in lipid concentrations which may suggest an altered metabolic response to w3 fatty acids. Therefore, the possible detrimental effect of the rise in total cholesterol and LDL cholesterol following fish oil administration may be offset by the increase in the protective HDL 2 subclass.