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ENHANCEMENT OF RENAL BUT NOT HAEMODYNAMIC EFFECTS OF ATRIAL NATRIURETIC PEPTIDE (1–28) IN SHEEP TREATED WITH ACTH
Author(s) -
Parkes David G.,
Coghlan John P.,
McDougall John G.,
Scoggins Bruce A.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01040.x
Subject(s) - atrial natriuretic peptide , medicine , endocrinology , diuretic , hemodynamics , blood pressure , kidney , blood volume , heart rate , cardiac output , intravascular volume status , natriuresis
SUMMARY 1. The haemodynamic and renal effects of short‐term infusion of human atrial natriuretic peptide (ANP) (1–28) were examined in sheep treated with ACTH and compared with the responses previously observed in normotensive sheep. 2. Infusion of ANP at 100 μg/h for 60 min in ACTH‐treated sheep (5 μg/kg per day for 5 days) decreased blood pressure and produced a fall in both cardiac output and stroke volume. No changes were seen in heart rate and total peripheral resistance. 3. ANP produced large increases in urine volume, urinary sodium and chloride excretion, and further decreased plasma potassium concentration in the ACTH‐treated sheep. Compared with normal sheep studied previously under the same conditions, the ACTH‐treated sheep showed a much greater diuretic and natriuretic response to ANP, although the blood pressure response to ANP was similar in both states. 4. The change in renal responsiveness to ANP in sheep may be related to the increased blood volume of the ACTH‐treated animals because volume expansion is known to enhance the renal effects of ANP.