Premium
MET‐ENKEPHALIN AND THE ENKEPHALIN ANALOGUE FK‐33824 CENTRALLY INHIBIT ADRENOCORTICOTROPHIC HORMONE SECRETION IN SHEEP
Author(s) -
Wang Xiaoming,
Tresham Janette J.,
Scoggins Bruce A.,
Coghlan John P.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01029.x
Subject(s) - endocrinology , medicine , (+) naloxone , enkephalin , opiate , adrenocorticotrophic hormone , met enkephalin , chemistry , endorphins , antagonist , hormone , opioid , receptor
b 1. The effects of central administration of met‐enkephalin, leu‐enkephalin, the enkephalin analogue FK‐33824 and the opiate antagonist naloxone on plasma concentration of adrenocorticotrophic hormone (ACTH) were examined in conscious sheep. 2. Intracerebroventricular infusion of met‐enkephalin and FK‐33824 significantly decreased the basal plasma concentration of ACTH. 3. Intracerebroventricular infusion of FK‐33824 inhibited the haemorrhage‐induced increase in plasma concentration of ACTH. 4. Intracerebroventricular infusion of naloxone attenuated the central inhibition of plasma concentration of ACTH induced by FK‐33824, but intravenous infusion of naloxone had no effect on the reduction in plasma concentration of ACTH induced by FK‐33824. 5. These studies suggest that in sheep met‐enkephalin may play a central inhibitory role in the control of ACTH secretion.