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EFFECTS OF NALOXONE ON GLUCOSE LEVEL IN THE HEPATIC VENOUS PLASMA IN THE RAT
Author(s) -
Pacula Piotr,
Janicki Piotr K.,
Krząścik Pawel
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb02427.x
Subject(s) - (+) naloxone , endocrinology , medicine , basal (medicine) , plasma glucose , opioid receptor , in vivo , endogenous opioid , chemistry , opioid , plasma levels , receptor , biology , insulin , microbiology and biotechnology
SUMMARY 1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals ( P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control ( P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.