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WHOLE BLOOD PLATELET AGGREGATION IS NOT AFFECTED BY CIGARETTE SMOKING BUT IS SEX‐RELATED
Author(s) -
Taylor R. R.,
Sturm M.,
Vandongen R.,
Strophair J.,
Beilin L. J.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb01888.x
Subject(s) - platelet aggregation , cigarette smoking , platelet , medicine , physiology , environmental health
SUMMARY 1. In normal subjects, 18–49 years old, the effects of the smoking habit (>10 cigarettes/day) and the act of smoking two cigarettes over 10 min were studied on whole blood platelet aggregation ( in vitro impedance method). 2. Acute smoking ( n = 10) did not affect platelet aggregation to ADP, collagen or to platelet activating factor (PAF) nor thromboxane B 2 production during aggregation. There was no difference between smokers ( n = 13) and non‐smokers ( n = 10). However, aggregation to all aggregants was greater in females ( n = 11) than males ( n = 12) (ADP and collagen, P <0.001; PAF, P <0.01; ANOVA). 3. Although others have obtained diverse results studying platelet‐rich plasma, the absence of an effect of cigarette smoking on whole blood platelet aggregation is consistent with many of those observations. Greater in vitro aggregability in females than males is consistent with the few studies of platelet‐rich plasma. It seems unlikely that the role of cigarette smoking as a risk factor for ischaemic heart disease is related to a direct effect on platelet aggregability.