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AUTORADIOGRAPHIC LOCALIZATION OF RECEPTORS IN THE MAMMALIAN CARDIOVASCULAR SYSTEM
Author(s) -
Summers R. J.,
Molenaar P.,
Stephenson J. A.,
Jones C. R.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00995.x
Subject(s) - muscarinic acetylcholine receptor , endocrinology , medicine , adrenergic receptor , receptor , blood vessel , guinea pig , vascular smooth muscle , circulatory system , biology , chemistry , smooth muscle
SUMMARY 1. Autoradiographic techniques have been used to examine the location of β‐adrenoceptors in the heart and β‐adrenoceptors, substance P receptors and muscarinic cholinoceptors in blood vessels. 2. Both β 1 ‐adrenoceptors and β 2 ‐adrenoceptors were present in guinea‐pig and human heart, on the myocardium and associated with the cardiac nerves and blood vessels. 3. Nerves on the vasculature and vascular smooth muscle contained β‐adrenoceptors and muscarinic cholinoceptors. 4. Receptors for substance P and β‐adrenoceptors, but not muscarinic cholinoceptors were present on endothelial cells.