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DISSOCIATION BETWEEN CORTICOTROPHIN AND CATECHOLAMINE RESPONSES TO ISOPRENALINE IN HUMANS
Author(s) -
Eisenhofer G.,
Goldstein D. S.,
Stull R. W.,
Gold P. W.,
Keiser H. R.,
Kopin I. J.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00980.x
Subject(s) - isoprenaline , catecholamine , endocrinology , medicine , chemistry , stimulation
SUMMARY 1. The pituitary‐adrenocortical, sympathoadrenomedullary and renin‐angiotensin‐aldosterone systems contribute to circulatory and metabolic homeostasis during stress. One possible site of co‐ordination of these systems is the β‐adrenoceptor. 2. To determine whether circulating β‐adrenoceptor agonists can act hormonally to stimulate these systems simultaneously, plasma concentrations of corticotrophin (ACTH), noradrenaline, adrenaline and plasma renin activity were measured during graded intravenous infusions of isoprenaline in 20 people. 3. Administration of isoprenaline caused dose‐related increases in noradrenaline (94% at the highest dose) and renin activity (189%), but decreases in ACTH (25%) and adrenaline (20%), findings inconsistent with simultaneous activation of these systems by circulating β‐adrenoceptor agonists.