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MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD
Author(s) -
Morris M. J.,
Pilowsky P. M.,
Minson J. B.,
West M. J.,
Chalmers J. P.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00966.x
Subject(s) - microinjection , medulla oblongata , microinjections , rostral ventrolateral medulla , kainic acid , spinal cord , medulla , neuropeptide , neuropeptide y receptor , medicine , endocrinology , chemistry , anesthesia , central nervous system , receptor , glutamate receptor , psychiatry
SUMMARY 1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline‐containing neurons. 2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y‐like immunoreactivity into the spinal subarachnoid space. 3. These data provide evidence for a functional bulbospinal neuropeptide Y‐containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.