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THE EFFECTS OF NALOXONE, DEXAMETHASONE, DEOXYCORTICOSTERONE AND 17‐HYDROXYPROGESTERONE ON BLOOD PRESSURE RESPONSES OF NORMAL AND ADRENALECTOMIZED RATS DURING HYPOVOLAEMIC SHOCK
Author(s) -
Khalid B. A. K.,
Moral Paden,
Merican Zainuddin
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00964.x
Subject(s) - (+) naloxone , shock (circulatory) , dexamethasone , medicine , endocrinology , antagonist , opioid antagonist , blood pressure , receptor
SUMMARY 1. The roles of, and interactions between, steroids and naloxone, an opioid antagonist, in the reversal of experimental hypotensive shock were studied in normal and adrenalectomized rats. 2. In normal rats treated with dexamethasone or deoxycorticosterone or 17‐hydroxyprogesterone the hypotension and shock caused by 1% bodyweight and 2% bodyweight haemorrhage could be substantially reversed by naloxone in a dose‐related manner. In contrast, the reversal of hypotension by naloxone was markedly less in adrenalectomized rats. 3. It is concluded that there is a co‐ordinate release of pressor catecholamines and depressor enkephalins from adrenal glands in hypovolaemic shock. Eventually, the use of naloxone would be of much less value in the treatment of hypotension or shock in patients with Addison's disease.