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THE EFFECT OF β‐ADRENOCEPTOR BLOCKERS ON THE ABSORPTION AND EXCRETION OF CHLOROTHIAZIDE IN MAN
Author(s) -
Adebayo G. I.,
Oyenuga A. B.,
Mabadeje A. F. B.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00963.x
Subject(s) - chlorothiazide , absorption (acoustics) , pharmacology , excretion , chemistry , medicine , endocrinology , diuretic , materials science , composite material
SUMMARY 1. The effect of β‐adrenoceptor blockers on the absorption and elimination of the diuretic chlorothiazide was studied in healthy subjects. 2. A week of pretreatment with either pindolol (10 mg twice daily) or propranolol (80 mg twice daily) resulted in significant reduction in 36 h mean cumulative urinary recovery of chlorothiazide in two groups of six subjects compared with a control (untreated) group. 3. A week of pretreatment with atenolol (100 mg daily) did not significantly alter 36 h cumulative urinary excretion in another group of six subjects. 4. None of the β‐blockers significantly changed chlorothiazide half‐life. 5. It is suggested that the non‐selective (as opposed to the cardioselective) β‐blockers reduce chlorothiazide absorption by the mechanism(s) discussed.