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DOSE‐RESPONSE RELATIONSHIPS FOR ADRENOCORTICOTROPHIN‐INDUCED HYPERTENSION IN MAN
Author(s) -
Whitworth Judith A.,
Gordon Deanna,
Scoggins Bruce A.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00958.x
Subject(s) - blood pressure , medicine , microgram , endocrinology , anesthesia , chemistry , biochemistry , in vitro
SUMMARY 1. Adrenocorticotrophin (ACTH), given as long‐acting Synacthen depot (Ciba‐Geigy), at 1000 μg/day, in divided doses 12 hourly, is known to increase blood pressure in man. 2. Fifty μg/day of short‐acting Synacthen given intravenously produced a rise in blood pressure and may be a threshold dose. 3. Twelve hourly intramuscular injections of short‐acting Synacthen over the dose range 100–400 μg/day was not sufficient to raise blood pressure.