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THE EFFECT OF CORTICOSTEROID PRETREATMENT IN VIVO ON THE CONTRACTION OF GUINEA‐PIG ILEUM AND DUODENUM
Author(s) -
Morat Paden,
Khalid B. A. K.,
Merican Z.,
Idid S. Z.,
Alias A. K.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00954.x
Subject(s) - ileum , duodenum , acetylcholine , contraction (grammar) , medicine , endocrinology , chemistry , muscle contraction , stimulation , contractility
SUMMARY 1. The effects of corticosteroid pretreatment on the contraction caused by acetylcholine or electrical stimulation of guinea‐pig ileum and duodenum were studied. 2. The acetylcholine dose‐response curves for steroid pretreated ileum but not duodenum were significantly shifted to the right; evidence that pretreated ileum required higher dose of acetylcholine than normal to cause 50% maximal contraction. 3. Naloxone enhanced the contraction of normal ileum caused by acetylcholine given at the dose of ED 50 , but not that of normal duodenum. 4. The dose of morphine required to abolish electrically induced contraction was higher in steroid pretreated ileum than in normal ileum. 5. Hence, corticosteroid pretreatment may affect intestinal contractility via opioidergic mechanisms which are found in the ileum but not in the duodenum.