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THE EFFECTS OF SIMULTANEOUS ATROPINE AND LABETALOL ADMINISTRATION ON CARDIOVASCULAR PARAMETERS DURING ANTICHOLINESTERASE POISONING IN ANAESTHETIZED CAT
Author(s) -
Merican Zainuddin,
Mahmud Zahari,
Morat Paden,
Idid Syed Zahir,
Bi Khatiza
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00950.x
Subject(s) - atropine , labetalol , blood pressure , heart rate , anesthesia , medicine
SUMMARY 1. The effects of atropine administration during anticholinesterase poisoning on heart rate, blood pressure and electrocardiographic changes (ECG) were studied in the cat. 2. Administration of atropine intravenously during anticholinesterase poisoning caused a significant increase in heart rate and blood pressure; ECG changes were also seen. 3. The simultaneous intravenous administration of atropine and labetalol during anticholinesterase poisoning abolished the increase in blood pressure and heart rate; ECG readings remained normal. 4. It is suggested that labetalol may be a useful adjuvant in the treatment of anticholinesterase poisoning especially in patients with compromised heart function.