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ANGIOTENSIN II‐INDUCED CONTRACTION OF MESANGIAL CELLS IN ACUTE RENAL ARTERY STENOSIS IN DOGS
Author(s) -
Anderson W. P.,
Alcorn D.,
Gilchrist A. I.,
Ryan G. B.
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00388.x
Subject(s) - renal artery stenosis , contraction (grammar) , medicine , angiotensin ii , cardiology , stenosis , renal function , kidney , renal artery , blood pressure
SUMMARY 1. Renal artery stenosis was induced in anaesthetized dogs, and the kidney rapidly fixed after 30 min. 2. Electron microscopy revealed marked folding of the paramesangial basement membrane in stenotic kidneys ( n = 7). The extent of this folding was significantly less in dogs treated with captopril ( n = 6). 3. It is suggested that this folding reflects angiotensin II‐induced contraction of the mesangial cells, which may help maintain glomerular filtration rate following stenosis.