Premium
THE URIDINE NUCLEOTIDES CONSTITUTE A NATRIURETIC PRESSOR SYSTEM
Author(s) -
Macdonald Graham,
Assef Rhonda,
Watkins Stan,
Burrell Judith
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00385.x
Subject(s) - uridine , natriuresis , medicine , nephron , endocrinology , chemistry , nucleotide , kidney , perfusion , biochemistry , biology , rna , gene
SUMMARY 1. Uridine monophosphate was tested in the conscious rat for natriuretic properties and an immunoperoxidase technique was used to localize uridine‐containing compounds in the rat kidney. 2. Uridine monophosphate, infused in a moderate pressor dose, caused a significant natriuresis compared to the effect of control infusions of solvent vehicle. 3. Uridine‐containing compounds were found in most tubular elements with particularly dense staining in the distal and collecting tubules. 4. While the increased sodium excretion may have been due to increased renal perfusion pressure, the high density of uridine staining in distal nephrons suggests that the uridine nucleotides have a specific nephron function, possibly relating to sodium transport.