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EFFECT OF GRADED LOW‐DOSE NORADRENALINE INFUSIONS ON NORADRENALINE CLEARANCE IN NORMALS AND ESSENTIAL HYPERTENSIVES
Author(s) -
Gordon Richard D.,
Bachmann Anthony W.,
Gueizelar Brenda,
Dai Yung
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00369.x
Subject(s) - endocrinology , medicine , essential hypertension , basal (medicine) , plasma clearance , chemistry , plasma concentration , plasma levels , metabolism , clearance , pharmacokinetics , blood pressure , urology , insulin
SUMMARY 1. In normal subjects and essential hypertensives, plasma noradrenaline (NA) levels, and NA clearance ( 3 H‐NA constant infusion), were measured during graded infusion of NA. 2. Plasma levels of NA were similar in both groups, with parallel increases to levels approximately three times basal, but still in the upper normal range. 3. Clearance did not increase in either group with increasing plasma NA levels. There was no correlation between plasma NA achieved and NA clearance, which was similar in hypertensives and normotensives. 5. Insofar as plasma clearance reflects tissue clearance, these studies provide no support for the contention that altered NA metabolism might predispose to elevated NA levels in essential hypertension.