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INFLUENCE OF ALCOHOL AND CAFFEINE CONSUMPTION ON CAFFEINE ELIMINATION
Author(s) -
George J.,
Murphy T.,
Roberts R.,
Cooksley W. G. E.,
Halliday J. W.,
Powell L. W.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02414.x
Subject(s) - caffeine , alcohol , chemistry , alcohol consumption , ethanol , consumption (sociology) , pharmacology , biochemistry , medicine , social science , sociology
SUMMARY 1. Ten healthy male volunteers were each studied on four separate occasions to assess the role of regular caffeine and alcohol intake on caffeine elimination. Antipyrine disappearance was also studied as an established quantitative test of hepatic microsomal function. 2. Regular caffeine intake in high doses for 1 week failed to alter either antipyrine or caffeine pharmacokinetics. 3. In contrast, alcohol intake of 50 g/day significantly prolonged caffeine half‐life by 72% ( P <0.005) and diminished caffeine clearance by 36% ( P <0.0005). However, antipyrine kinetics were unaltered. 4. These results demonstrate that alcohol, in amounts commonly consumed, is a strong inhibitor of caffeine metabolism.