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STREPTOKINASE ALTERS MYOCARDIAL CREATINE KINASE DEPLETION AFTER ISCHAEMIA AND REPERFUSION IN RABBITS
Author(s) -
Mickelson J. K.,
Carlson C. J.,
Margaretten W.,
Rapaport E.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02392.x
Subject(s) - streptokinase , medicine , creatine kinase , myocardial infarction , cardiology , occlusion , coronary occlusion , anesthesia , ischemia , infarction , artery , saline
SUMMARY 1. The efficacy of streptokinase as an intracoronary thrombolytic agent is wellrecognized. The effect of streptokinase, distinct from its thrombolytic action, on ischaemic myocardium distal to an area of coronary artery occlusion when reperfusion occurs has not been well‐defined. 2. In order to do this, myocardial creatine kinase depletion and the histopathology of infarctions produced in rabbits after 1 h of circumflex coronary artery occlusion and mechanical release of the occlusion were assessed. 3. Streptokinase or saline was infused intravenously for 1 h beginning 0.5 h after occlusion. Rabbits were divided into two time intervals: early (<10 h) and late (24 h) after release of coronary artery occlusion. 4. When streptokinase was infused in early infarctions, haemorrhage did not correlate with infarction cross‐sectional area or myocardial creatine kinase depletion. However, myocardial creatine kinase depletion was 40% less when streptokinase was infused than when saline was infused, suggesting that streptokinase might limit infarct size. 5. In late infarctions, the degree of haemorrhage, infarction cross‐sectional area, and myocardial creatine kinase depletion were similar after reperfusion with streptokinase or saline. By 24 h, the beneficial effect of a single dose of streptokinase given early in the course of occlusion‐reperfusion myocardial injury was no longer evident in limiting infarct size.