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ALDOSTERONE RESPONSES TO ACTH DURING HYPOXIA IN CONSCIOUS RATS
Author(s) -
Raff Hershel,
Chadwick Karen J.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02388.x
Subject(s) - aldosterone , medicine , endocrinology , hypoxia (environmental) , adrenocorticotropic hormone , endogeny , chemistry , hormone , oxygen , organic chemistry
SUMMARY 1. This study examined the aldosterone response to physiological ACTH infusion (4 ng/kg per min) and pharmacological ACTH injection (1.8 μg) in conscious Long‐Evans rats at 42 h of normoxia (21% O 2 ) or hypoxia (10% O 2 ). 2. Hypoxia per se (no exogenous ACTH) significantly decreased control aldosterone levels despite elevated endogenous plasma ACTH). 3. Hypoxia attenuated the aldosterone responses to ACTH infusion but not to ACTH injection. 4. It was concluded that hypoxia attenuates aldosterone responses to small increases in ACTH, and large increases in ACTH can override this apparent decrease in adrenocortical sensitivity.