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CAPTOPRIL DOES NOT POTENTIATE HYPOTENSION AND ALGESIA BY SUBSTANCE P
Author(s) -
Hui SC. G.,
Ogle C. W.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02386.x
Subject(s) - captopril , medicine , pharmacology , substance p , anesthesia , blood pressure , neuropeptide , receptor
SUMMARY 1. Captopril (1–5 mg/kg, i.v.) did not affect the vasodepressor responses to substance P (1–30 μg/kg, i.v.) in anaesthetized rats. 2. Substance P (100 μg/kg, s.c.) produced significant algesia in mice; this was not potentiated by the smaller doses of captopril (1–2 mg/kg, i.p.), but was instead antagonized by the high dose (5 mg/kg, i.p.). 3. It is concluded that captopril does not have any influence on substance P degradation in vivo since the pharmacological actions of the undecapeptide are not enhanced after captopril treatment.