Premium
THE EFFECT OF HIGH FREQUENCY OSCILLATORY VENTILATION ON EXTRAVASCULAR LUNG WATER IN THE RABBIT
Author(s) -
Ritchie B. C.,
Brodecky V.,
Scott A.,
Wilkinson M. H.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02385.x
Subject(s) - ventilation (architecture) , lung , medicine , high frequency ventilation , anesthesia , cardiology , mechanical ventilation , mechanical engineering , engineering
SUMMARY 1. High frequency ventilation (HFV) systems have the theoretical advantage of producing less barotrauma and lung damage because of the associated smaller oscillations in alveolar pressure compared to conventional ventilators. 2. An index of lung damage is an increase in extravascular lung water but previous studies using HFV have produced conflicting results. 3. Lung wet‐to‐dry ratio, extravascular lung water and blood mass were measured in 30 rabbits divided into three groups ( n = 10); spontaneously breathing (SV), conventional positive pressure ventilation (CV) and high frequency oscillatory ventilation (HFV). 4. HFV maintained normal blood gases and produced a significant reduction in the wet‐to‐dry weight ratio compared to SV and CV ( P < 0.05). Extravascular lung water and blood mass were significantly reduced in HFV compared to SV ( P < 0.05). 5. It is concluded that the system of HFV used in this study has clinical potential in the treatment of lung injury.