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PROPRANOLOL AMELIORATES EXERCISE‐INDUCED REGIONAL MYOCARDIAL DYSFUNCTION IN DOGS
Author(s) -
Mayer N.,
Krumpl G.,
Schneider W.,
Raberger G.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02383.x
Subject(s) - propranolol , contractility , medicine , cardiology , heart rate , blood pressure , treadmill
SUMMARY 1. The effects of propranolol (0.5 mg/kg) on exercise‐induced regional myocardial dysfunction were investigated in an animal model with limited coronary reserve. 2. Limited coronary reserve was accomplished in conscious, chronically instrumented dogs by external filling of a hydraulic cuff occluder placed on a coronary vessel which did not impair resting myocardial function but induced severe dysfunction during treadmill exercise. 3. Propranolol led to a distinct reduction of heart rate, myocardial contractility and systolic blood pressure, thereby ameliorating exercise‐induced regional myocardial dysfunction.