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ERYTHROCYTE WATER CONTENT IN SPONTANEOUSLY HYPERTENSIVE RATS AND DOCA‐SALT HYPERTENSIVE RATS
Author(s) -
Kawarabayashi T.,
Yasunari K.,
Kanayama Y.,
Takeuchi K.,
Takeda T.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb02382.x
Subject(s) - spontaneously hypertensive rat , medicine , endocrinology , chemistry , blood pressure
SUMMARY 1. Intra‐erythrocyte water, sodium and potassium contents were measured in spontaneously hypertensive rats (SHR) and deoxycorticosterone acetate (DOCA)‐salt rats. 2. In 12 week old SHR, the intra‐erythrocyte water content was slightly but significantly lower than that in age‐matched Wistar‐Kyoto (WKY) rats. SHR also exhibited a significantly lower intra‐erythrocyte potassium content, but sodium content tended to be elevated. 3. Although sodium content was not correlated with the water content, potassium content was. 4. In DOCA‐salt hypertensive rats, the intra‐erythrocyte sodium content was higher than that in age‐matched normotensive Sprague‐Dawley rats by about 33%, but the water and potassium contents were similar. There were no significant correlations between these parameters. 5. These findings provide no evidence of water retention in erythrocytes from DOCA‐salt rat or SHR even though intra‐erythrocyte sodium content was increased.