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EFFECT OF L ‐THYROXINE ON SERUM ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN SHEEP *
Author(s) -
Verma P.,
Noble S.,
Miller R.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00945.x
Subject(s) - endocrinology , medicine , enzyme , angiotensin converting enzyme , renin–angiotensin system , angiotensin ii , enzyme assay , discontinuation , chemistry , serum concentration , receptor , blood pressure , biochemistry
SUMMARY 1. The effect of l ‐thyroxine on serum angiotensin converting enzyme activity using a sheep model was examined. 2. Following two weeks of l ‐thyroxine treatment, the activity of serum angiotensin converting enzyme was increased from 6.92 U/ml to 8.65 U/ml (s.e.m. = 0.40, n = 13, P <0.01). 3. Discontinuation of l ‐thyroxine treatment resulted in lowering the activity of serum angiotensin converting enzyme within three weeks to values close to those observed during the control period. 4. It was concluded that l ‐thyroxine modulates serum angiotensin converting enzyme activity. The sheep is an appropriate animal model for the study of the factors that control serum angiotensin converting enzyme activity.