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TEMPORAL PROFILE OF TISSUE LEVELS OF DOPAMINE AND ITS METABOLITES, HVA AND DOPAC FOLLOWING FOCAL CEREBRAL ISCHAEMIA IN ANAESTHETIZED PRIMATES
Author(s) -
Kuruvilla A.,
Cherian R.,
Theodore D. R.,
Abraham J.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00934.x
Subject(s) - homovanillic acid , substantia nigra , basal ganglia , dopamine , medicine , endocrinology , occlusion , chemistry , anesthesia , central nervous system , dopaminergic , serotonin , receptor
SUMMARY 1. Occlusion of the middle cerebral artery produced ischaemia and consequent changes in basal ganglia in the primate model of stroke within 0.5 h. 2. Dopamine content was decreased in the right basal ganglia from 0.5 h up to 12 h after occlusion. 3. Homovanillic acid content of the right basal ganglia increased initially at 0.5 h but, was decreased at 12 h. 4. The DOPAC content was increased at 2 h after occlusion in the right basal ganglia, but was decreased significantly at 12 h. 5. In the substantia nigra, there was a significant reduction in the DA content in the right side at 12 h. 6. Minimal changes were observed in the DOPAC and HVA content in the right substantia nigra at 2 h and 4 h, respectively. At other time periods there was no significant change in the content of HVA and DOPAC in substantia nigra.