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EFFECT OF SALT LOADING ON BLOOD PRESSURE AND EICOSANOID METABOLISM OF SPONTANEOUSLY HYPERTENSIVE RATS FED A FISH OIL ENRICHED DIET
Author(s) -
Codde J. P.,
Croft K. D.,
Beilin L. J.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00365.x
Subject(s) - eicosanoid metabolism , eicosanoid , blood pressure , fish oil , fish <actinopterygii> , metabolism , endocrinology , medicine , chemistry , dietary salt , food science , biology , biochemistry , arachidonic acid , fishery , enzyme
SUMMARY 1. This study investigated the effects of dietary modification of prostaglandin (PG) synthesis on blood pressure regulation in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats under conditions of normal and elevated salt intake. 2. After an initial period of 4 weeks on either a 2‐series PG ‘inhibitory’ diet offish oil (maxEPA) or a control diet of saturated fat, half of each group received 1.5% saline for 1 week. 3. Blood pressures were unaffected by diet during the period of normal salt intake, but following salt loading, the maxEPA‐fed SHR showed a blood pressure increase (mean = 21 mmHg) relative to the EPA‐fed rats on water. 4. Rats on maxEPA showed impaired ability to generate serum thromboxane and diminished excretion of urinary 6‐keto‐PGF 1 α and PGE 2 . SHR on water showed greater serum TXB 2 generating capacity than WKY, but diminished urinary PGE 2 excretion. 5. Thus, the increased blood pressure observed in the salt‐loaded SHR on the maxEPA diet may be explained by reduced renal PG synthesis resulting in either mild sodium retention and/or increased vascular reactivity.