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CAPTOPRIL ANTAGONIZES THE HYPOTENSIVE ACTION OF ATRIAL NATRIURETIC PEPTIDE IN THE ANAESTHETIZED RAT
Author(s) -
Nicolantonio Robert Di,
Stevens Janine,
Weaver Debbie,
Morgan Trefor O.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00354.x
Subject(s) - captopril , atrial natriuretic peptide , angiotensin ii , medicine , endogeny , renin–angiotensin system , antagonism , endocrinology , pharmacology , blood pressure , receptor
SUMMARY 1. Atrial natriuretic peptide (8‐33; ANP) caused a prolonged hypotensive response following intravenous injection in anaesthetized rats. 2. This response was abolished by captopril treatment and restored by concomitant angiotensin II infusion. 3. These results suggest that ANP exerts its hypotensive action in the anaesthetized rat by the antagonism of the vasoconstrictor action of endogenous angiotensin II.