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NEUROMUSCULAR BLOCKING ACTIVITY OF A CRUDE AQUEOUS EXTRACT OF IPOMOEA FISTULOSA
Author(s) -
Abdelhadi A. A.,
Elkheir Y. M.,
Hassan T.,
Mustafa A. A.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00332.x
Subject(s) - blocking (statistics) , ipomoea , chemistry , aqueous extract , traditional medicine , botany , biology , medicine , mathematics , statistics
SUMMARY 1. The rat phrenic nerve hemidiaphragm and chick biventer‐cervicis preparations were used to investigate the effect of a crude aqueous extract of Ipomoea fistulosa. 2. Electrically‐induced skeletal muscle twitches of the hemidiaphragm were blocked by the extract and by tubocurarine. 3. The anticholinesterase, physostigmine, intensified the blockade by the extract. 4. The extract produced contracting of the chick biventer‐cervicis preparation. 5. It is suggested that the extract possesses neuromuscular blocking activity of a depolarizing nature.