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NATRIURETIC AND HYPOTENSIVE EFFECTS OF α‐HUMAN ATRIAL NATRIURETIC POLYPEPTIDE IN ANAESTHETIZED DOCA‐SALT HYPERTENSIVE RATS
Author(s) -
Kondo K.,
Kida O.,
Kangawa K.,
Matsuo H.,
Tanaka K.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00322.x
Subject(s) - natriuresis , medicine , endocrinology , blood pressure , atrial natriuretic peptide
SUMMARY 1. Both natriuretic and hyportensive effects of α‐human atrial natriuretic polypeptide (α‐hANP) were investigated in anaesthetized DOCA‐salt hypertensive rats and control rats. 2. An intravenous injection of two doses (0.3 and 3.0 μg/kg body weight) of α‐hANP produced a rapid and marked increase in natriuresis and fall in blood pressure in DOCA‐salt rats. 3. Natriuretic and hypotensive effects of α‐hANP in DOCA‐salt rats were significantly greater than those in the control rats. 4. It is suggested that DOCA‐salt rats may have an enhanced natriuretic and hypotensive responsiveness to α‐hANP.