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DISTRIBUTION AND KINETICS OF INJECTED NICKEL IN THE PREGNANT RAT
Author(s) -
Mas A.,
Peligero M. J.,
Arola LI.,
Alemany M.
Publication year - 1986
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1986.tb00321.x
Subject(s) - kinetics , chemistry , distribution (mathematics) , kidney , nickel , endocrinology , medicine , tissue distribution , pancreas , radiochemistry , andrology , biochemistry , biology , mathematical analysis , physics , mathematics , organic chemistry , quantum mechanics
SUMMARY 1. Radioactive nickel (Ni) was injected intraperitoneally both carrier‐free and in 4 mg/kg body weight of Ni as NiCl 2 doses in control and pregnant rats on days 12 and 19 after impregnation. 2. The time‐course of disappearance of radioactivity from the tissues and blood of the rat was determined, as well as the degree of incorporation of radioactivity from the injected doses. 3. The maximal uptake of the metal 15 min after injection corresponded to kidney uptake, followed by pancreas, blood plasma and then all other target organs studied. The presence of cold nickel resulted in higher uptake of the metal without much change in the proportion of distribution between tissues. The kinetics of disappearance was similar in all tissues and was little affected by pregnancy, with mean half‐lives of about 3‐5 h irrespective of doses.