Premium
TOTAL BODY SODIUM IN IMMATURE SPONTANEOUSLY HYPERTENSIVE AND WISTAR KYOTO RATS
Author(s) -
Harrap Stephen B.,
Doyle Austin E.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb02652.x
Subject(s) - sodium , blood pressure , natriuresis , endocrinology , medicine , high sodium , chemistry , organic chemistry
SUMMARY 1. Total body sodium of male and female spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats was estimated weekly during the first 8 weeks of life by measuring exchangeable sodium (ENa). Blood pressure and sodium intake was measured from weeks 4 to 8. 2. SHR had significantly higher blood pressure and sodium intake than WKY from 4 to 8 weeks of age. 3. ENa was higher in SHR than WKY throughout the first 8 weeks of life. 4. Relative sodium retention was observed in SHR during weeks 5 to 8 despite a significant rise in SHR blood pressure and fall in sodium intake. 5. These findings suggest a change in the renal pressure/natriuresis relationship at this age in the SHR.