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RETARDED DEVELOPMENT OF HYPERTENSION IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS FOLLOWING CHRONIC ALCOHOL CONSUMPTION
Author(s) -
Howe P. R. C.,
Rogers P. F.,
Smith R. M.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb02646.x
Subject(s) - blood pressure , alcohol , medicine , alcohol consumption , ethanol , body weight , stroke (engine) , spontaneously hypertensive rat , endocrinology , alcohol intake , anesthesia , chemistry , biochemistry , engineering , mechanical engineering
SUMMARY 1. The influence of chronic alcohol consumption on blood pressure was examined in normotensive Wistar/Kyoto rats (WKY) and in stroke‐prone spontaneously hypertensive rats (SHR‐SP). 2. Ethanol, administered in drinking water from 5 weeks of age to produce moderate blood alcohol levels, substantially retarded the development of hypertension in SHR‐SP and caused a mild reduction of blood pressure in WKY. 3. Alcohol withdrawal caused an acute rise in blood pressure in both strains, followed by a reduction to the subnormal levels previously induced by alcohol treatment. 4. This sustained antihypertensive effect of alcohol was not attributable to reductions of body weight or fluid intake.