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INCREASED RENAL PROSTANOID SYNTHESIS AFTER UNCLIPPING THE ONE‐KIDNEY, ONE‐CLIP HYPERTENSIVE RAT: EFFECT OF RENAL DENERVATION
Author(s) -
McGowan Helen,
Anderson Helen,
Barden Anne,
Vandongen Robert
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb02642.x
Subject(s) - denervation , endocrinology , medicine , blood pressure , kidney , renal artery , chemistry
SUMMARY 1. Renal denervation of hypertensive one‐kidney, one‐clip (1K, 1C) rats resulted in a minor fall in blood pressure (216, s.e.m. = 4, to 182, s.e.m. =4, mmHg) 24 h later, which returned to predenervation levels within 1 week. 2. Subsequent unclipping led to a similar fall in blood pressure in denervated (202, s.e.m. = 4 to 142, s.e.m. = 3) and sham‐denervated (211, s.e.m. = 5 to 147, s.e.m. = 4) rats. 3. Unclipping also resulted in a marked rise in urinary PGE 2 and 6‐keto PFG 1α in both denervated and sham‐denervated animals. 4. It appears that 1K, 1C hypertension, 8 weeks after clipping, is only slightly dependent on renal nerves. 5. Unclipping results in increased renal synthesis of PGE 2 and PGI 2 which is not dependent on intact renal innervation.