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IS ALDOSTERONE/RENIN RATIO USEFUL TO SCREEN A HYPERTENSIVE POPULATION FOR PRIMARY ALDOSTERONISM?
Author(s) -
Hamlet S. M.,
Tunny T. J.,
Woodland E.,
Gordon R. D.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb02641.x
Subject(s) - primary aldosteronism , aldosterone , medicine , renin–angiotensin system , hyperaldosteronism , plasma renin activity , essential hypertension , endocrinology , urology , blood pressure
SUMMARY 1. The ratio of aldosterone to renin in plasma was measured in samples collected from 79 hypertensive patients. 2. Eighteen patients with primary aldosteronism had ratios ranging from 25 to 677 (mean 183) when measured on 34 occasions, while 16 normal subjects had ratios of 3.3–21 (mean 11.3). 3. Of the remaining 61 patients with ratios ranging from 1.8 to 184, 15 patients have ratios greater than 25 and are under investigation for primary aldosteronsim, which appears highly likely in five and has been excluded in two. 4. The aldosterone/renin ratio appears promising as a screening test for primary aldosteronism. Consistency and the effects of sodium and potassium balance and of antihypertensive medications require further study.