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MECHANISM OF ACTION OF NATRIURETIC FRACTION OF URINE
Author(s) -
Chakravarty Bhaskar J.,
Gillies Alastair H. B.,
Carney Shane L.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb02638.x
Subject(s) - calcium , chemistry , stimulation , natriuresis , sodium , medicine , endocrinology , ouabain , potassium , organic chemistry
SUMMARY 1. The nature of calcium dependence of natriuretic fraction (NF)‐induced contractions in the rat smooth muscle anococcygeus and a possible correlation between the effect of NF on sodium transport and its natriuretic potency was investigated. 2. NF and noradrenaline‐induced contractions were partially dependent on external calcium concentration. Ouabain and potassium (K) free solution (KoPSS)‐induced contractions were totally dependent on external calcium and were more effectively inhibited by calcium antagonists than those of NF and noradrenaline suggesting pharmacomechanical coupling as the mode of calcium dependence of NF. 3. Like other agonists which contract by pharmacomechanical coupling, NF stimulted sodium transport ( 86 rubidium uptake) in dog saphenous vein. Such stimulation correlated positively ( r = 0.495, n = 17, P <0.05) with the natriuretic potency of NF. 4. NF, like noradrenaline, contracts smooth muscle by pharmacomechanical coupling and NF‐induced natriuresis is associated with stimulation of the sodium pump.