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DIGITALIS RECEPTORS AND DIGOXIN SENSITIVITY IN RENAL FAILURE
Author(s) -
Malini Pier Luigi,
Strocchi Enrico,
Feliciangeli Giorgio,
Buscaroli Andrea,
Bonomini Vittorio,
Ambrosioni Ettore
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb02313.x
Subject(s) - digoxin , digitalis , in vivo , receptor , cardiac glycoside , in vitro , pharmacodynamics , pharmacology , chemistry , medicine , endocrinology , heart failure , biology , ouabain , pharmacokinetics , biochemistry , microbiology and biotechnology , organic chemistry , sodium
SUMMARY 1. The number and the in vitro and in vivo affinity of digitalis receptors for digoxin were measured in patients with normal renal function and in uraemics. 2. In uraemic patients the number of receptors was decreased. Although their in vitro affinity for digoxin was unchanged the in vivo affinity was decreased, probably due to hyperkalaemia. 3. These findings provide a possible pharmacodynamic explanation for decreased activity of cardiac glycosides in chronic renal failure.