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THE EFFECT OF THE 'HYPERTENSINOGENIC STEROID, 9α‐FLUORO‐CORTISOL ON BLOOD PRESSURE IN SHEEP WITH ACTH‐INDUCED HYPERTENSION
Author(s) -
Mills Eric H.,
Coghlan John P.,
Denton Derek A.,
Nelson Mark A.,
Spence Campbell D.,
Whitworth Judith A.,
Scoggins Bruce A.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00912.x
Subject(s) - endocrinology , medicine , blood pressure , urine , excretion , steroid , heart rate , alpha (finance) , urinary system , chemistry , hormone , surgery , construct validity , patient satisfaction
SUMMARY 1. The effect of treatment with 9α‐fluorocortisol (9aFF), a steroid which causes hypertension in sheep, was examined in sheep with ACTH‐induced hypertension. 2. ACTH treatment alone increased mean arterial pressure (MAP), plasma Na concentration, water intake and urine volume and decreased plasma K concentration. 3. 9αFF treatment, for 3 days during continuing ACTH administration, did not change blood pressure but increased heart rate, water intake and urine volume and decreased urinary K excretion. 4. As 9αFF did not cause a further increment in blood pressure in sheep with ACTH‐induced hypertension it is possible that both ACTH and 9αFF may produce hypertension by similar mechanisms.